China Online News, July 17th (Sun Guogen, Chen Jing) The reporter was informed on the 17th that Chinese scholars found that during three years, in a large clinical cohort study: frequent sleepiness during the day, insufficient sleep at night or too much sleep can increase cognitive impairment Risk; and sleeping 6-7 hours a night can reduce the risk of cognitive impairment.
With the support of major national and Shanghai research projects, Professor Yu Jintai, Department of Neurology, Huashan Hospital Affiliated to Fudan University, and Professor Tan Lan, Department of Neurology, Qingdao University, published the research results in the latest issue of the top international journal in this field. The Alzheimer's Disease and Dementia Journal has attracted widespread attention in the international medical community.
Yu Jintai advocated that in order to prevent the occurrence of cognitive impairment and dementia, attention should be paid to sleep management.
According to Yu Jintai, the research team has established a large-scale clinical research database and biological sample database of cognitive impairment. Based on the established CABLE cohort (Chinese Alzheimer's disease biomarker and lifestyle study), the researchers deeply explored the various physiological characteristics of sleep on the pathophysiological changes of Alzheimer's disease (the most common type of dementia) influences.
The research team was the first to confirm the U-shaped relationship between nighttime sleep time and the pathogenesis of Alzheimer's disease in the middle-aged and elderly population at the biomarker level, and to biologically confirm the sleep characteristics by affecting the deposition of amyloid Can increase the risk of Alzheimer's disease.
According to reports, amyloid deposition is a key factor in inducing Alzheimer's disease and one of the core pathological features of Alzheimer's disease. The researchers found that lack of sleep or too much can promote abnormal deposition of amyloid in the body; daytime dysfunction, such as frequent sleepiness during the day, can also promote abnormal deposition of amyloid in the body.
Yu Jintai told reporters that the research team also carefully plotted the evidence system linking sleep and cognitive impairment risk, and found that 10 types of sleep characteristics (disorders), including insomnia, can accelerate cognitive impairment. The researchers further analyzed and found that the nighttime sleep time has a U-shaped relationship with the risk of Alzheimer's disease: that is, the optimal nighttime sleep duration may be between 5.6 and 7 hours; the nighttime sleep time is less than 4 hours or more than 10 hours. The risk of knowledge barriers will increase significantly. (Finish)