We have always believed, whether we are ordinary citizens or doctors, that the new corona, the virus that was recorded in only one day, the nineteenth of June this year, 180 thousand infections globally, is a respiratory infection of the type that may cause pneumonia, develop In a small percentage of cases, the SARS becomes more severe, which in turn causes a significant number of deaths. But when Elnara Marcia Negri (1), researcher and pulmonologist at the Faculty of Medicine at the Brazilian University of Sao Paulo, tried to examine a number of functional criteria for the lung of one of her patients on March 25, she found something strange.
"The oxygen level in this patient's blood was very low, but nonetheless she was breathing normally, which is not normal," says Negri in her interview with the online editor, " Meydan ". In a case like this, the patient’s lung was supposed to start locking in a lot of carbon dioxide, which pushes a message to her brain asking the lung muscles to continue to work at greater rates, which is what causes the patient to breathe more quickly, as if ascending quickly on the steps of a long ladder.
But this did not happen. At that point, a Nigerian thought about a hypothesis saying that the problem of this lady may not be related to the lung itself itself but to a lack of oxygen due to small clots in the small blood vessels of the lung, especially since this lady faced problems in the toes indicating this, causing that The stroke is that oxygen does not pass from the blood vessels in the lung to the rest of the body, and at the same time the brain does not sense the problem and the patient breathes normally.
"We gave the patient anti-coagulant drugs, and the result was that her respiratory problems stopped, and her condition improved," says Negri in her interview with Maidan . In fact, that was not the result of just one case (2), but 27 other cases improved with this new protocol, and while recovery was supposed to take 28 days normally, those cases improved in less than 14 days.
Negeri was one of the first to point out that "Covid-19" can cause these clots, which can travel to all parts of the body causing severe damage to the organs, it was in the kidneys or the heart, or even the brain, where the new corona can kill its patients Stroke. But what is surprising is that only the new Corona - without its companions - is just what it does.
To get a deeper understanding of this idea, let's compare "Covid-19" with the usual flu in advanced cases, where a multinational research team dissected seven lungs of people who died due to having "Covid-19" compared to another group of lungs of people who died from an advanced case of influenza The results were released last May in the prestigious and famous New England Journal of Medicine (3).
In both cases, severe damage was expected in the lung air sacs. We already know that respiratory illnesses may develop from pneumonia to acute respiratory distress syndrome (ARDS). These are symptoms, as these follicles are filled with dead and pus cells and the remnants of a severe immune battle that occurred There is between the body and the virus.
But in the case of the deaths of "Covid-19" only, there were effects of severe damage to the cellular lining that covers the blood vessels from the inside (endothelium), with large amounts of the virus in the cells of those layers, and a large number of clots in the blood vessels, in her conversation with "Meydan". "The effect of those cells that cover the vessels from the inside is what causes the stimulation of blood clotting," Negeri says. "Also, the severe inflammatory response due to the disease stimulates the clotting. It starts in the blood vessels surrounding the lung and then goes to all parts of the body."
In fact, the hypothesis that the new corona permeates the cells that line the blood vessels and causes them to become damaged, which in turn stimulates coagulation in the blood, spreads from the lung to the rest of the body, which is one of the most important causes of death, has been remarkable since its appearance, especially since there Certain groups of people are more acceptable to this type of development because of problems encountered in their blood vessels, and they are the same categories that we know are a dangerous criterion in "Covid-19": those with high blood pressure, for example, diabetes, and obesity, and men are more susceptible to this type of The damage is from women, smokers more than non-smokers.
After arriving at preliminary results on the use of anticoagulants, Negri, along with her comrades from the same college, Marisa Dolnikov and Paolo Saldeva, became interested in the idea of autopsy of the patients of "Covid-19 ″, and their study in this scope was the first of its kind, and it was published in the Journal of Thrombosis & Homestays "(4).
"The autopsies showed an enormous number of clots in the small vessels in the lung and also in the small vessels of other organs such as the kidneys, heart, skin, etc., and clots were also found in major blood vessels," Negri told Medan . Stopping the development of these clots, they develop to cause severe respiratory distress, and kill the patient.
These results are confirmed by several studies, for example a research team from the ancient Mount Sinai Hospital had recently produced the results of (5) new anatomical experiments, the largest to date, on 67 dead bodies due to "Covid-19 ″, the results showed the presence of clear clots in the lung And other organs, especially the kidneys, liver, and brain, but what was remarkable in that study were the brain effects.
Although the brain was less affected by the inflammations caused by "Covid-19 ″, it showed a surprising number of clots in the small blood vessels, with evidence of the death of some brain tissue due to the blockage of blood vessels in both the peripheral and deep parts of the brain, which It can explain some of the psychological changes that appear in some patients.
Indeed, a group of studies (6) had recently been issued to several multinational research teams, based its direct experiments on the creature members in the laboratory, had indicated that the new Corona virus - itself - is what travels in the blood stream of these organs and directly infects them, and it was Scientists believe that the effect of "Covid-19" on non-lung organs is not direct, meaning that the virus causes lung damage, which in turn affects other organs.
"These results dramatically change how we treat patients with Covid-19 ″," says Negri in her interview with Meydan , explaining that it will be important to start preventing blood clotting and maintaining patient moisture immediately with any sign of hypoxia in the blood. This, while we are talking, has already entered into many therapeutic protocols on a global scale.
What is “Covid-19 ″? In its simplicity, this question remains a big question mark. Sometimes it is just a“ minor cold role ”that comes with some cold or headache, at other times it appears as a rash or loss of sense of smell and taste, and it may It appears in the form of diarrhea and intestinal symptoms, but besides that, it may appear as a malfunction of the heart or kidneys or - of course - the lungs, now we know that it causes blood clots in the whole body and may kill its patient due to a stroke or a stroke in the heart, for example!
When we examine patients, we find new corona everywhere in the body, in the throat, lung, tears, stool, kidney, liver, pancreas, heart, and brain, but we find it in the fluid around the brain and spinal cord! On the other side, we still do not know many answers to basic questions related to the disease, for example: What is the nature of our immune responses to it? How many people have it? Will he continue to arrive seasonally?
At the end of her conversation with Meydan , Negeri notes that more research is required to be able to tame this branching disease in almost all of the human body, until the vaccine arrives. Therapeutic protocols are developing day after day with additions such as those provided by Negeri and her companions, which have reduced the proportion of deaths worldwide by a full 1% by arriving at the end of this June compared to April, so perhaps that helps us day after day to overcome a crisis that is The most cruel in our history since the Second World War!
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