Corona virus is fading fast in Britain and decreasing in France .. Thailand is trying to vaccinate monkeys

Dr.. Osama Abu Al-Rub

An Oxford University expert said the emerging SARS Cove 2 virus, which causes Covid 19, appears to be fading fast in Britain. While the number of Corona patients has decreased in France's hospitals, Thailand has begun testing an anti-virus vaccine for monkeys.

We start in Britain, where Adrian Hill, co-chair of the University of Oxford's production of a vaccine against Covid-19, said the chance of a successful trial did not exceed 50% because the Corona virus seemed to be fading quickly in Britain.

Hill - who is director of the Jenner Institute at Oxford University who collaborated with AstraZeneca drug maker to develop the vaccine - said it was expected that a future trial of 10,000 volunteers would not lead to a result due to a decline in Covid-19 transmission in society.

"It is a race against the disappearance of the virus and a race against time," Hill told the Telegraph newspaper. "At this moment there is a 50% chance that we will not achieve a result at all."

This experimental vaccine is among the leading vaccines in the global race to provide protection against the emerging corona virus. The Hill team had started the early stages of human vaccine trials last April.

Monkeys

And an official said that Thailand began testing experiments on an anti-virus vaccine against the Corona virus in monkeys, after positive tests conducted in mice.

The Minister of Higher Education, Science, Research, and Development, Sofitel Masence, said the researchers had transferred the vaccine experience to the monkeys, and he hoped they would find a "clearer result" of its efficacy by next September.

"This project is for all people, and not for the Thais. The Prime Minister has set a policy that obligates us to participate in the development of a vaccine that we join the international community's work force in this regard," he told reporters.

Thailand announced on Wednesday its work to develop a vaccine, which is among at least 100 others being developed globally, and said it hoped to complete production by next year.

Sofitel said Thailand had started mandating two manufacturers to produce its vaccine against Covid-19. The vaccine that Thailand develops relies on RNA, which stimulates the cells of the body to produce bodies and molecules on the surface of the virus to stimulate the immune system to function.

In France, the number of Corona patients in hospitals decreased on Saturday, with 205 patients recovering, bringing the total number of hospitals currently to 17,178, in a continuation of a gradual decline that started more than five weeks ago when the number reached a peak of 32,292 patients on April 14th.

The number of those in intensive care decreased by 2.1%, with 36 patients discharged, to 1665 currently.

Request a review

On Saturday, French Health Minister Olivier Ferrand requested a review of the rules governing the prescription of a number of drugs, including hydroxychloroquine, after a study showed its ineffectiveness and the risks of its use in treating Covid-19.

"After the publication of The Lancet, a study warns of the dangers of some drugs and their ineffectiveness in the treatment of Covid-19, including hydroxychloroquine, I asked the Supreme Council of Public Health to carry out an analysis of the study and submit a proposal within 48 hours to review the rules governing prescriptions."

France had banned the use of hydroxychloroquine outside the framework of clinical trials, and authorized its use only in hospitals and exclusively to treat serious injuries, based on the decision of the doctors ’committees.

Since late February, the drug derived from the anti-malarial drug chloroquine has become popular after the director of the University Hospital Hospital in the Mediterranean in Marseille Didier Raoul published a brief and detailed, Chinese study that concluded that there were indications of the effectiveness of chloroquine phosphate in treating people with the SARS-Cove virus. 2 ".

A few days ago, US President Donald Trump revealed that he had been taking for ten days as a preventative measure of the anti-malarial drug, Hydroxychloroquine, which Brazil had recommended to treat minor infections with the emerging coronavirus.

Two recent studies, Chinese and French, showed that the drug hydroxychloroquine did not significantly reduce cases of admission of patients with Covid-19 intensive care units, nor deaths of patients receiving hospital treatment for pneumonia caused by Covid-19.

For his part, Professor Tofan Tokak, Dean of the Faculty of Medicine of Istanbul University, said in statements to Anatolia that "hydroxychloroquine appeared at the beginning as a treatment for malaria, but it is not used in Turkey a lot because of the non-spread of this disease."

Tokak explained that the main area of ​​the drug currently is the treatment of rheumatism and arthritis, and that it has no serious side effects if used in the treatment of rheumatism.

He pointed out that Turkey began using the drug early with China after it became clear that it helps prevent the proliferation of the Corona virus inside the cell if it was used at the beginning of the disease. Tokak noted that there was a discussion two months ago regarding the feasibility of using hydroxychloroquine for preventive purposes.

He stated that Turkish doctors felt that using the drug for the purpose of preventing the disease had no benefit, but could be harmful because of its side effects.

He explained, "There are reports that the drug caused sudden death, but it has not yet been proven."

Show that the treatment is used in specific doses and a special protocol applied by the Ministry of Health, and it makes no sense to use it without infection with the Coronavirus.

Tokak emphasized that the use of hydroxychloroquine is beneficial for patients, but that it may be harmful if used for preventive purposes.

Unknown effects

Prof. Ismail Murt Fural, an pharmacologist and faculty member at the University of Health Sciences in Istanbul, said, "Hydroxychloroquine has been used since 1950 to treat malaria, lupus, rheumatoid arthritis, Sjogren's syndrome, and to treat other connective tissue diseases."

Fural added that "the drug prevents the entry of the Corona virus into the cells and its multiplication, as well as prevent tissue damage by preventing it secrete cytokine."

He pointed out that hydroxychloroquine modifies the immune system and eliminates some symptoms such as inflammation, pain and high body temperature.

He stressed that "the drug is used in Turkey since the beginning of the infection Corona unlike the way it is used in the rest of the world." He reported that its use in early treatment and the general condition of the patient greatly influence the success of the treatment.

He explained that the effects of using hydroxychloroquine for the purpose of prevention are "still unknown".

Voral saw that the drug has serious side effects according to the dose of its use and in the event of taking it for a long time, including a heart rhythm disorder, and its effect on the health of the eyes.