Cheng Jing, a representative of the National People's Congress and an academician of the Chinese Academy of Engineering, suggested that the state should develop a "smart network for intelligent monitoring of major epidemics", using a series of biosensors deployed in medical institutions, using 5G communication, big data and artificial intelligence technology to combine the detection data Push to facilitate decision-making on first-hand epidemic information. He revealed that the vehicle-mounted fully integrated on-site rapid detection chip system for common pathogens of the respiratory tract, which can accurately, conveniently and quickly detect the new coronavirus, is under urgent research and is expected to be put into use as soon as July.

　　Beijing News News The National People's Congress representative and academician of the Chinese Academy of Engineering Cheng Jing recently interviewed by the Beijing News revealed that the vehicle-mounted fully integrated on-site rapid detection chip system for common pathogens of the respiratory tract that can accurately, conveniently and quickly detect the New Coronavirus is under emergency investigation. It will be put into use as soon as July.

　　Currently, the new coronavirus is still raging in many countries. China is bordered by more than 10 countries. Its land border is 22,000 kilometers long. There are many ports of entry, and the natural environment and medical conditions vary greatly. How can we ensure that the new coronavirus is blocked outside the country?

　　Accurate and rapid virus identification is the first step. The central government ’s response to the New Coronary Pneumonia Epidemic Work Leading Group has repeatedly asked for improved testing capabilities. The May 15 meeting proposed: "Accelerate the work related to improving testing capabilities and expanding testing scope, highlighting the development of more accurate, convenient, and rapid testing equipment and reagents. Production, increase the training of testing personnel. "

　　Cheng Jing, representative of the National People's Congress and the head of Beijing National Engineering Research Center and Boao Bio-Group Co., Ltd., said that he is currently developing a vehicle-mounted fully integrated on-site rapid detection chip system for common pathogens of the respiratory tract (also called vehicle New Coronavirus Testing Laboratory). At present, a fully integrated nucleic acid detection chip that can produce results within 50 minutes, a portable clinical sample pre-processing instrument, an oral pharyngeal swab sampling robot that can avoid operator infection caused by manual sampling operations, and a modified car that can be equipped with a laboratory, etc. A series of key projects are being carried out in an orderly and orderly manner, and some of them have been completed. It is expected to be put into use as soon as July. The on-board laboratory can flexibly and conveniently carry out the detection of new coronavirus nucleic acid, and it will play an important role in application scenarios such as clustered outbreaks at border ports and communities.

　　A transparent disc shaped like an optical disc, with a diameter of less than 10 cm, is divided into different functional areas by various micro-pipes and groove-shaped reaction cells ... Cheng Jing said that this is the first fully integrated closed nucleic acid rapid detection chip in China , Recently approved as a national emergency project, will soon enter the State Administration of Drug Administration for emergency approval.

　　The so-called full integration means that the chip is closed immediately after the sampled sample enters the chip. Afterwards, the three groups of functions of sample processing, biochemical reaction and result detection do not require manual intervention, and all are completed automatically.

　　Other parts of the on-vehicle new coronavirus testing laboratory, including the rapid inactivation pre-processing instrument for self-developed clinical samples of medical device declarations, the oral pharyngeal swab sampling robot developed by the Department of Mechanical Engineering of Tsinghua University, and car modification, are under development.

　　Cheng Jing suggested that the country should develop a direct reporting system for major epidemic analysis instruments, use a series of biosensors deployed in medical institutions, and use 5G communication, big data and artificial intelligence technology to combine the detection data directly to facilitate the first-hand Decisions based on outbreak information. This is the "Smart Monitoring Skynet for Major Epidemic Situations".

　　■ Dialogue

　　Fast introduction of six respiratory multiviral nucleic acid detection chips

　　The detection sensitivity of the latest chip has been greatly improved

　　Beijing News: After the outbreak of the new crown, Boao quickly launched a kit that can detect six kinds of respiratory nucleic acid viruses at one time. What advantages does it have compared with single index detection products?

　　Cheng Jing: The biochip has the characteristics of high throughput. Before this new coronavirus outbreak, we have developed two kinds of chips, one is 13 kinds of respiratory pathogen nucleic acid detection chips, which have been approved by the Food and Drug Administration; the other is 19 kinds of respiratory virus nucleic acid detection chips. The suggestions and opinions of academicians Zhong Nanshan and Li Lanjuan took the rare one of the 19 viruses and put the new coronavirus on it. Due to time constraints, it was not possible to complete the clinical trials of all 19 viruses, so only six of the most common were later declared.

　　The most frequently diagnosed patients in winter and spring may be influenza A, B, or bacterial infections. Boao's multi-index nucleic acid detection chip products can detect them at once, and it only takes one and a half hours. It can not only help medical staff to quickly identify new coronavirus infections, but also effectively identify patients with influenza and patients with new coronary pneumonia.

　　Beijing News: How are these chips used?

　　Cheng Jing: Our products are built into systems, and the instruments are universal. Since the approval of the respiratory pathogen nucleic acid detection chip kit in 2016, nearly 400 large hospitals across the country have introduced our detection system. On February 22 this year, six respiratory virus nucleic acid detection kits were approved by the State Food and Drug Administration for emergency approval ( Registration certificate number: National Machinery Injection Standard 20203400178), many hospitals have introduced this chip.

　　Beijing News: There is an inaccurate situation in nucleic acid detection, can our chip filter out some interference?

　　Cheng Jing: False negative test results are caused by many factors. Any detection method has a detection limit. For any detection product, it will only be detected when the concentration of the substance being detected is higher than its detection limit. Technically, the sensitivity of the reagent needs to be improved. The latest chip developed by us has greatly improved the detection sensitivity, which can reach 300 copies / ml, and the time is shortened to less than one hour.

　　Beijing News: The process of biochips is complicated, will it cause unaffordable problems?

　　Cheng Jing: Actually, biochips are different from electronic chips used in mobile phones and computers. It is a consumable, so we have to control its cost. The price of biochips is set by the national price department. The pricing rules do not ask you whether it is complicated, but are set according to the number of viruses detected, whether they are immunoassays or genetic tests. We have controlled on technical means and materials, so we can achieve lower prices, and even some foreign colleagues do not believe that we can make it.

　　Development of a new car virus detection laboratory

　　Beijing News: Why should we develop a new car virus detection laboratory?

　　Cheng Jing: After the outbreak, we received many national-level R & D tasks to do emergency research and development. For example, in the early stage of epidemic prevention, some ports do not even have decent hospitals, and they do not have advanced nucleic acid detection methods, but the new coronavirus is a strong virus, so we urgently need to develop a closed type that can be tested in ordinary environments , Fully automatic vehicle-mounted rapid response laboratory. In the process of collecting pharyngeal swabs, manual operation should be avoided, so an oral pharyngeal swab sampling robot must be developed; rapid virus inactivation requires automation, and a clinical sample pre-inactivation pre-treatment instrument needs to be developed; there are large differences in the climate and temperature of the detection site across China To maintain a stable and constant temperature environment, you need to be a vehicle-mounted testing laboratory, so you have to modify the car ... involving many products to be developed. Therefore, at the beginning of March, Tsinghua University was presided over by the president himself, and a special anti-epidemic commando was established for this purpose.

　　Because it is vehicle-mounted and flexible, such as a mass outbreak in a community, driving a car carrying a testing laboratory to sample and test can reduce the risk of further virus transmission caused by the movement of people.

　　Beijing News: The current prevention and control of the new coronavirus has entered the normal stage, will your research and development also be a continuous process?

　　Cheng Jing: Yes. The performance of the product is constantly improving. For example, the chip used to be semi-automatic. It takes one and a half hours to produce the results. The latest fully integrated closed new crest virus detection chip can be completed within 50 minutes, and the detection sensitivity is higher.

　　At the same time, we have more and more knowledge about the virus. For example, we find that it is constantly mutating. If the key points of the viral gene sequence change, it may not be detected. Therefore, virus detection and treatment will be a long-term process.

　　Recommends the integrated health management for all people

　　Beijing News: Do you have any suggestions for improving the public health system?

　　Cheng Jing: Two proposals are being considered this year. One is for the occurrence of this epidemic. It is recommended that the country should establish a “Skynet for Intelligent Monitoring of Major Epidemic Situations” as soon as possible in order to deal with new and sudden infectious diseases that may occur again in the future The other is to continue to call for suggestions on general health and treatment of the disease. That is, prevent disease first. It is necessary to carry out integrated health management of the whole people. This is a combination of traditional Chinese medicine and modern scientific and technological means, which will keep our traditional medicine upright and innovative and carry forward, so that our culture and civilization will be accepted by the world through the medical window.

　　Taking the 100,000-person community diabetes screening we conducted in Chongqing as an example, we obtained the health economics index, which is 1: 25.67. In other words, it takes a dollar to take the initiative to do diabetes screening. If you wait for diabetes to go to treatment, you need to spend 25.67 yuan. The problem is that diabetes is basically a lifelong drug dependence, which can cause various complications in severe cases. After we get rid of poverty in an all-round way, if the number of wealthy diseases is not well controlled, the three highs may overwhelm us.

　　Therefore, we consider active screening and active management of the three highest populations. After completing a 100,000 community diabetes screening in Chongqing, it was found that the number of people who had diabetes but did not know it was higher than the number of people diagnosed with diabetes. This situation can only be intervened in advance through active screening.

　　Beijing News reporter Sha Xueliang