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Scientists discover 10 new genes that increase the risk of schizophrenia

2019-10-22T17:58:14.744Z



According to a new study, scientists have discovered 10 genes that play a key role in the development of schizophrenia, a mental illness that affects up to 1% of society.

Schizophrenia is also known as schizophrenia. According to the National Mental Health Foundation in the United States, schizophrenia affects 1% of the population.

Schizophrenia does not mean that a person has multiple personalities. It is also a misconception that a schizophrenic patient has two struggling characters, one evil or abnormal for the person and the other together, and that the treatment is one victory over the other.

Researchers at Massachusetts General Hospital and Harvard Medical School have found that the risk of the disease rises when parts of the chromosomal DNA, which are proteins that help brain cells communicate effectively, are found to be at risk, according to Natalie Rahal.

Complex case
Schizophrenia is a complex psychological condition and scientists hope that identifying genetic and environmental risk factors for the disease will help make better treatments.

In fact, schizophrenia is an attractive subject for those researchers and people who do not suffer from this condition. As for those suffering from an incomprehensible mental illness, schizophrenia can be exhausted. Although antipsychotic treatment can be very effective, its use has been associated with atrophy for years.

The development of new drugs to treat schizophrenia could improve the lives of 3.2 million Americans with the condition in the United States.

"The development of drugs for schizophrenia has been limited over the past 50 years," said Tarjinder Singh, a post-doctoral researcher at Harvard University in the field of psychiatry. "But over the past decade, we have begun to make discoveries in genetics that help us better understand The main objective of our research is to understand the genetic causes of schizophrenia and encourage the development of new therapies. "

To achieve this, Singh and his team carried out one of the widest genetic screenings for schizophrenia ever made. They studied chromosomal DNA data for more than 125,000 people, knowing in advance that about 25,000 had schizophrenia. They found similarities in the genomes of those with schizophrenia, such as delusions, hallucinations, confused thoughts and speech.

Production Instructions
"For the first time, we were able to identify 10 genes. When they break down, the risk of schizophrenia increases dramatically. Two of these 10 genes give instructions to the body to produce a special protein," Singh said.

These proteins, called glutamate receptors, are one of the most important proteins that make up the way brain cells interact with each other. Therefore, when these genes are tampered with, the internal communication system in the brain is disrupted.

Although there is still a long way to go, the realization that disrupting glutamate DNA raises the risk of schizophrenia would give researchers a new goal to help them develop treatments for the condition. "Our analysis has revealed that many of these genes exist, and our research is just the beginning," Singh said.

Source: aljazeera

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