China News Service, Shanghai, May 24 (Sun Guogen and Chen Jing) The reporter learned on the 24th that Chinese and foreign scholars jointly conducted research and found that long-term exposure to PM2.5 will significantly accelerate the deterioration of cognitive function.
People with high exposure to air pollution can prematurely develop Alzheimer's disease (AD) pathological changes in their brains, resulting in cognitive impairment.
This study provides a key biological rationale for establishing a causal link between air pollution-induced cognitive decline.
Prof. Yu Jintai from Huashan Hospital Affiliated to Fudan University, together with Prof. Kan Haidong and Prof. Chen Renjie from School of Public Health, Fudan University, Prof. Zeng Yi from Peking University, Prof. Feng Qiushi and Feng Lei from Singapore University, Prof. Chen Huashuai from Xiangtan University, Prof. Tan Lan from Qingdao University, etc. The research results jointly obtained by well-known domestic scholars have been published in the latest issue of the international academic journal Biological Psychiatry.
According to reports, scholars have studied the risk effects of exposure concentrations of the three most common air pollutants, fine particulate matter (PM2.5), ground-level ozone and nitrogen dioxide in different time windows, and believe that continuous reduction of air pollution exposure may greatly reduce air pollution exposure. Reduce the burden of dementia disease, which should be considered in public health policy decisions and primary prevention of Alzheimer's disease.
According to Yu Jintai, with the aging of China's population, the prevalence of Alzheimer's disease continues to increase, but limited by the scarcity of key biological samples such as cerebrospinal fluid, the impact of air pollution on the pathological formation of Alzheimer's disease has not been best interpretation.
Yu Jintai's team used social sciences to investigate the China Longitudinal Health and Longevity Survey (CLHLS) cohort, and applied it to lead the establishment of a large-scale neurobiological China Alzheimer's Disease Biomarkers and Lifestyle (CABLE) research data to systematically carry out the above questions. Multilevel research.
The research team used the Intelligent Mental State Examination Scale to score cognitive function.
Studies have shown that an increase of 20 μg per cubic meter of PM2.5 exposure can increase the risk of cognitive decline by 10%.
Individuals living in areas with high exposure to PM2.5 have poor overall cognitive ability, the rate of change in scale scores reflecting overall cognitive function is significantly increased, and the in vivo indicators of high amyloid load reflecting core pathology of AD are significantly abnormal .
Yu Jintai and Tan Lan emphasized that reducing exposure to air pollutants (especially PM2.5) is of great significance for producing considerable health and social benefits.
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