Science and Technology Daily, Beijing, April 28 (Reporter Zhang Mengran) In a review article published in the journal "Cell" on the 28th, Walter Lange, a professor at the Leonard Davis School of Gerontology at the University of Southern California, and co-authors at the University of Wisconsin Rozarin Anderson describes the "macrobiosis diet," a multi-pillar approach based on research on all aspects of the diet, from food composition to calorie intake.

　　Langer believes that by examining a range of results from laboratory animal studies to human epidemiological studies, scientists are getting a clearer picture of what nutrients can lead to longer, healthier lives.

　　"We explored the links between nutrition, fasting, genes and longevity in ephemeral species and linked these links to clinical and epidemiological studies in primates and humans, including centenarians." Lange Say.

　　The researchers report that the key features of an optimal diet appear to be moderate to high carbohydrate intake from unrefined sources, small but adequate protein intake from predominantly plant-based sources, and sufficient plant fat to provide About 30% of energy requirements.

Ideally, meals are served in an 11-12 hour window throughout the day, allowing for daily fasting, and a 5-day fast every 3-4 months may also help reduce insulin resistance, blood pressure, and other disease risks factor.

　　Lange describes what a macrobiotic diet looks like in real life: lots of legumes, whole grains and vegetables; some fish; no red or processed meat and very little white meat; low sugar and refined grains; some amount of nuts and olive oil ; some dark chocolate.

　　Lange said the next step would be a 500-person study in southern Italy.

The macrobiotic diet has both similarities and differences with the Mediterranean-style diets commonly found in super-aging "blue zones" such as Sardinia, Italy, Okinawa, Japan, and Loma Linda, California, USA.

These regions are known for having large numbers of people over the age of 100, and diets are often largely plant- or pessimistic and relatively low in protein.

　　Longer noted that macrobiotic diets should also be adapted to individuals based on gender, age, health status and genetic factors.

For example, people over 65 may need to increase protein to combat weakness and muscle loss, as Langer's own research shows that higher protein levels are better for people over 65, but not for those under 65. The best.

　　For those looking to optimize their diets to prolong life, it is important to work with a healthcare provider who specializes in nutrition to develop an individualized plan that focuses on smaller dietary changes that can be adopted throughout life, rather than large changes that can lead to significant losses.

Once people give up a very strict diet, body fat and weight return.