Alzheimer's disease affects around one million people in France, or 8% of French people over the age of 65 who would be affected in 2020, according to Vaincre Alzheimer.
Genetic predisposing factors are part of the causes of the disease, hence the importance of examining the genome.
A French team of scientists has managed to identify 75 regions of the genome associated with Alzheimer's disease, reports Futura.
42 had not yet been involved in the declaration of the pathology.
We owe this pan-genomic association study to researchers from Inserm, the Institut Pasteur de Lille, the University Hospital of Lille and the University of Lille.
The genetic data of 111,326 people who had been diagnosed with Alzheimer's disease, or who had relatives in this case, were studied.
Additionally, the scientists included 677,663 healthy controls.
Scientists have identified 75 regions of the #genome 🧬 associated with #Alzheimer's disease.
They also constructed a risk #score that helps to better assess disease progression in people with cognitive impairment.
👉https://t.co/IeYT3ffmJ7 pic.twitter.com/lbfCqpa21o
— Inserm (@Inserm) April 4, 2022
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Better understand cellular mechanisms and pathological processes
Drawing data from several large European studies, the researchers were able to analyze the entire genome in order to identify those that could be associated with the disease.
“After this important discovery, the rest of our work consisted in characterizing these regions of the genome that we had identified in order to give them meaning in relation to our biological and clinical knowledge, and therefore better understand the cellular mechanisms and pathological processes at the work," emphasizes Jean-Charles Lambert, Inserm research director.
The analyzes were able to confirm that several regions of the genome are involved in the production of amyloid peptides and in the functioning of the Tau protein, a protein that accumulates inside neurons.
Researchers have put forward other mechanisms.
They were also able to develop a genetic risk score, which makes it possible to assess the risks that a person victim of cognitive disorders may have of suffering from Alzheimer's, within three years after diagnosis.
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