For the first time, a national research group has published data on the efficacy and side reactions of "alternate vaccination," in which the third dose of the new coronavirus vaccine is given by a different manufacturer than the second dose.

When a person who had been vaccinated with Pfizer up to the second time hit Moderna the third time, the level of antibody that prevented infection increased compared to the person who hit Pfizer three times, but the rate of side reactions such as fever was high. It is said that.

A research group from the Ministry of Health, Labor and Welfare analyzed the first medical workers in Japan to start the third vaccination, and all the targeted people were vaccinated with Pfizer up to the second vaccination.



By the 28th of last month, 2826 people who received the third vaccination at Pfizer and 773 people who received the third vaccination at Moderna were analyzed for antibody levels and side reactions to the conventional strain before mutation, and were welfare on the 18th. I explained it at the expert group of the Ministry of Labor.

How effective is it?

Among these, we investigated how much the antibody level increased one month after the third vaccination for those who did not have the antibody due to infection compared to just before the vaccination. The average number of people who hit the test was 54.1 times, and the average number of people who were vaccinated with Moderna for the third time was 67.9 times.



Based on the results of overseas studies, it is presumed that the effect on the Omicron strain is also higher when the modelna is inoculated for the third time.

What are the side reactions?

Regarding side reactions,


those who had a fever of 38 degrees or higher after the third vaccination


▼ 21.4% were vaccinated with Pfizer all three times, ▼ 49.2% were vaccinated with Moderna at the third vaccination,



▽ Whole body The malaise was


▼ Physer 69.1%, ▼ Moderna 78%,



▽ Headache


▼ Physer 55%, ▼ Moderna 69.6%.



In both cases, the symptoms peaked the day after the inoculation, and almost subsided a few days later.



In addition, two cases of suspected "myocarditis", which causes inflammation of the heart muscle, were reported in people who hit Pfizer three times, but it was not a serious symptom.



No serious symptoms, including myocarditis, have been identified in those who hit Moderna for the third time.



* The subjects of antibody analysis are those who did not have antibodies due to infection as a result of blood test, 396 for the third Pfizer and 233 for Moderna.


* Vaccine reactions were analyzed for those who were able to collect diaries up to one week after vaccination, Pfizer for 2626 and Moderna for 437.

Research group representative "Judgment considering the balance between effects and side reactions"

Suminobu Ito, a visiting professor at Juntendo University School of Medicine, who is the representative of the research group, said, "While the antibody level increased when the modelna was inoculated for the third time, the frequency of side reactions was high, but the degree of taking sick leave was high. There was no change. I want you to decide which vaccine to choose by considering the balance between effects and side reactions. "

Third inoculation Major companies are moving ahead of schedule

In order to accelerate the third vaccination, the government is supporting occupational vaccinations at companies, etc., and major companies are moving ahead of schedule to inoculate occupational areas in earnest.



Of these, the Rakuten Group has moved the schedule 10 days ahead of schedule in response to the government's efforts, and started the third occupational vaccination on the 18th.

On the 18th, at the start of 10:30 am, employees and their families visited the venue set up at the head office in Setagaya-ku, Tokyo, and were vaccinated.



At the venue, doctors can ask questions online to improve the efficiency of the inoculation system, and we have established a system that allows up to 5,000 inoculations per day.



The Rakuten Group expects to inoculate about 25,000 times for employees and their families, and from the 14th of next month, it will start inoculating residents in Setagaya Ward, Kawasaki City, and Yokohama City. , Including our business partners, we are aiming for a total of 200,000 inoculations.



An employee in his thirties who had been vaccinated said, "There may be side reactions, but I was relieved to be able to get the vaccination early so that the infection would not spread around."

Kentaro Momono, Vice President of Rakuten Group, said, "I would like to do my best to accelerate vaccination and resume economic activities."



Nomura Holdings, ITOCHU, Softbank Group, etc. have been moving ahead with the schedule for the third occupational inoculation from this week, and occupational inoculation is in full swing among major companies.

12.6% of the total population who received the third vaccination

According to the latest situation announced by the government on the 18th, 169,146 people received the third dose of the new coronavirus vaccine in the country, accounting for 12.6% of the total population.



Of those who received the third vaccination, Pfizer's vaccine was 11,506,498, 71.9%, and Moderna's vaccine was 4,502,648, 28.1%.



In fact, inoculation may be more advanced than this, and it may increase in the future.


The entire population includes children under the age of vaccination.

Expert "Refer to the medical situation and the additional vaccination rate for the elderly, etc."

Atsuro Hamada, a specially appointed professor at Tokyo Medical University who is familiar with infectious diseases, said, "In Europe and the United States, we are rapidly moving toward returning our lives and socio-economy to before the epidemic of the new corona, but the number of newly infected people is finally increasing in Japan. At the stage of exceeding the peak, the vaccination rate of booster vaccination has still exceeded 10%. I think it is good to move toward returning the socio-economy in areas where the number of infected people is not large, but Tokyo, Osaka, etc. In areas where there are a large number of people, it is necessary to consider the cancellation of priority measures such as prevention of spread while referring to the medical situation and the rate of additional vaccinations for elderly people in particular. "

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