Covid today, last minute live | They identify a key genetic variant to survive Covid-19

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A study led by CIBERES researchers at the Health Research Institute of the Principality of Asturias, the University of Oviedo and the University Institute of Oncology of the Principality of Asturias has identified a genetic polymorphism that determines the prognosis of critical patients admitted to care units intensive (ICU) by

.

The identified polymorphism (

) is a variant of the IFIH1 gene, which encodes a protein, MDA5, responsible for the recognition of the viral genome in the cell cytoplasm.

After its union with the

, an interferon-mediated inflammatory response is triggered that will depend, according to the results of the study, on the gene variant carried by the patient.

update narration

07.33.

Masks are no longer mandatory in educational centers at recess and outdoor activities from this Thursday

The Community of Madrid has determined that from this Thursday the

will no longer be mandatory in educational centers "during recreation periods and in the development of other activities as long as they are carried out, in both cases, in open-air spaces".

This is stated in Order 168/2022 of the Ministry of Health that will be published this Thursday in the Official Gazette of the Community of Madrid (BOCM) by which Order 1244/2021, of October 1, is modified, with the aim to adapt it to the content of Royal Decree 115/2022, of February 8, on the mandatory use of masks during the health crisis situation caused by

.

This Royal Decree, published in the Official State Gazette (BOE), modulates the use of the mask abroad, generally eliminating the obligation to use it in outdoor spaces except in mass events and on platforms or stations. means of transport that are in the open air.

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07.18.

A study concludes that treating the coronavirus with convalescent plasma "is not effective"

The Lluita Foundation against AIDS and the Germans Trias i Pujol University Hospital --Can Ruti-- have explained that the treatment with convalescent plasma against

that they were testing "is not effective" after conducting a study.

In a statement this Wednesday, they have concluded that administering convalescent plasma with high antibody titers to patients with mild

in the first seven days of symptoms does not reduce progression to severe disease or hospitalization.

This type of passive immunotherapy that has been tested also has no effect on viral load, according to results published in Lancet Respiratory Medicine.

The study involved the participation of 376 non-hospitalized Catalan volunteers, half of whom were given an intravenous infusion of convalescent plasma, and the other half a placebo.

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07.00.

They identify a key genetic variant for survival by Covid-19

A study led by CIBERES researchers at the Health Research Institute of the Principality of Asturias, the University of Oviedo and the University Institute of Oncology of the Principality of Asturias has identified a genetic polymorphism that determines the prognosis of critical patients admitted to care units intensive (ICU) by

.

infection

.

An uncontrolled inflammatory response can cause even greater damage to the lungs or other vital organs, through mechanisms initially aimed at resolving the condition.

In order to limit this inflammatory response, dexamethasone is commonly used, a corticosteroid that has been shown to improve the survival of patients with

moderate-severe

The identified polymorphism (rs1990760) is a variant of the IFIH1 gene, which encodes a protein, MDA5, responsible for recognizing the viral genome in the cell cytoplasm.

After its union with the

, an interferon-mediated inflammatory response is triggered that will depend, according to the results of the study, on the gene variant carried by the patient.

Thus, patients carrying two T alleles (TT genotype) show an attenuated inflammatory response and a better prognosis, with much higher survival than those individuals with the CC/CT genotype.

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