The pregnant mother eats walnuts, the baby's brain is bright, the pregnant mother eats grapes, the baby's eyes are bright, the pregnant mother eats sesame, and the baby's hair is dark... If the pregnant mother is vaccinated, can the baby have antibodies?
Scientists at the Massachusetts General Hospital and the Ragon Institute have used scientific research to confirm this link - the antibodies produced by pregnant mothers who are vaccinated against the new crown can be detected in umbilical cord blood and in newborns. Baby is resistant to the new coronavirus.
A related paper was published in the Journal of the American Medical Association (JAMA) on February 7.
Pregnant mothers can give children two kinds of antibodies
It is well known that the nutrients ingested by the pregnant mother will be passed on to the baby, so can the antibodies also be passed on?
"There are two types of antibodies that mothers pass on to their babies, fetal-borne antibodies and milk-borne antibodies." An unnamed expert told the Science and Technology Daily reporter that the former is actively effluxed into the fetal blood circulation through the placenta, and the latter is When breast milk enters the baby's body, both antibodies help the baby acquire the ability to fight off pathogens.
For example, antibodies to infectious diseases such as influenza and hepatitis B have been confirmed to be passed from mother to baby.
So, are fetal-transmitted antibodies and milk-transmitted antibodies indispensable?
An interesting animal experiment has the answer.
Sinovac has previously conducted a "replacement" study in cooperation with the University of Sydney School of Medicine when researching a vaccine for hand, foot and mouth disease.
Four female mice, two groups were vaccinated and two groups were not.
After the pups were born, the vaccinated and unvaccinated litter of suckling mice were switched and fed, and the other two litters did not move.
Afterwards, four litters were challenged with enterovirus 71 virus, and the protective effects of fetal- and milk-borne antibodies were compared from the incidence and lethality of each littermate.
It was found that both fetal-transmitted antibodies and milk-transmitted antibodies produced a certain degree of protection, but when both were present, only the young mice were attacked by the virus to survive, and the protection was 100%.
New crown antibodies can also be transmitted
After the emergence of the new coronavirus, people's research on the new coronavirus antibody has become more and more in-depth, and many studies have begun to prove that the new coronavirus antibody can be passed to the baby through two channels.
As early as March 2020, scholars from Zhongnan Hospital of Wuhan University analyzed the in vivo antibody status of several mothers and newborns who were infected with the new coronavirus.
The results showed that the newborn had antibodies to the new coronavirus, but was not infected with the new coronavirus and showed no symptoms.
Since 2021, a number of reports from Turkey and Brazil have shown that anti-coronavirus antibodies were detected in umbilical cord blood and neonatal blood samples after pregnant women were vaccinated with Kexing's new crown vaccine Kellev. Specific IgA antibodies also appear in .
In January of this year, a study published in Obstetrics and Gynecology showed that American researchers injected breastfeeding women with the new crown vaccine, but detected new crown antibodies in the infants, proving that breast milk can pass the new crown antibodies to the baby. Give them immunity to Covid-19.
How about antibody staying power?
So how long does the resistance passed from mother to baby last?
New research shows that mothers who gain protection from vaccines pass on protection that lasts longer to their babies than mothers who contract the new coronavirus pass on to their babies.
Researchers at the Massachusetts General Hospital and the Ragon Institute included 77 vaccinated pregnant women and 12 pregnant patients with new coronavirus infection.
At 6 months, the researchers looked at 28 infants born to vaccinated mothers and found that 57 percent (16) still contained detectable antibodies.
In contrast, only 1 in 12 children of mothers who had contracted the virus had the antibody, or 8 percent.
It can be seen that most infants of vaccinated mothers have persistent resistance at 6 months, while many infants of infected persons are undetectable.
How is the security?
Unlike eating walnuts and grapes, expectant mothers have concerns about getting vaccinated against the new crown: Is it safe?
At present, my country's recommendation for pregnant women, pregnant women and lactating mothers is to suspend the vaccination of the new crown.
Relevant experts explained in the previous popular science question and answer that this is not because inactivated vaccines are harmful to these people and babies, but because there is currently no clinical sample size large enough to confirm the safety of such people after vaccination. Consider suspending vaccination due to the rigour and rigour.
With the mass vaccination, the safety verification of the new crown vaccine has been gradually improved.
For example, from April 2021 to August 2021, pregnant women in Brazil were vaccinated with a total of more than 250,000 doses of the new crown vaccine (including elderly women over 40 years old). Good safety profile in the maternal population.
"Other countries generally vaccinate these women due to the severity of the new crown epidemic." The aforementioned expert, who did not want to be named, said that in some countries, due to the high maternal mortality rate caused by the new crown pneumonia, pregnant women are included in the priority group for vaccination.
Regarding the evidence of the safety of mothers-to-be vaccinated against the new crown, the expert reminded that they should avoid falling into a circular "dilemma": because they dare not vaccinate pregnant women, there is no data on pregnant women's vaccination, and there is no scientific basis, let alone giving pregnant women. He believes that the current global epidemic is still at a high level, and scientific demonstrations should be deployed in advance to prepare for this group to obtain immunity to the new crown through vaccines.
Experts from the Chinese Center for Disease Control and Prevention have also pointed out that the use of new scientific evidence to adjust vaccines, vaccination procedures, vaccine policies and vaccination schedules, consolidate the herd immunity brought about by vaccines, and maintain protective immunity is the key to China's emergence from the pandemic.
Our reporter Zhang Jiaxing