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The
omicron
variant
is already predominant at least in Madrid and the Canary Islands, where it accounted for, respectively, 55.4% and 54.8% of the cases in the week of December 13 to 19.
This is reflected in the latest update on the epidemiological situation of
SARS-CoV-2
variants
in Spain published by the Ministry of Health.
According to the report, the percentage of infections associated with the omicron variant in the aforementioned week throughout the country is only 20.5%, although this figure
"could underestimate the intensity of the circulation of this variant at the present time
.
"
The current data "are not totally representative at the national level since, despite the fact that the samplings are carried out randomly, the absence of data from some communities (especially in the most recent weeks) and the different proportion in which each contributes one of them limits the interpretation of this information ", the document acknowledges.
In general, the information available from sequencing and PCR screening "indicates that
there is a rapid replacement of the delta variant by omicron,
" the paper notes. "Given the speed with which this expansion is taking place, the delay in obtaining and communicating the results means that the values reflected in the weeks included in the report may underestimate the intensity of the circulation of this variant at the present time" .
The growth rate of omicron is being "very fast"
, the Health technicians confirm in the report.
"We already have data from two or three weeks for several communities, which allows us to appreciate a very rapid growth trend. Considering the set of samples analyzed at the national level, the percentage of samples compatible with omicron
multiplied by 10 between the week 48 and 49
", they point out.
Variant impact
"In Spain, it has gone very quickly from detecting the first cases associated with travelers from South Africa to detecting cases linked to community transmission and noting a rapid growth in surveillance systems based on sequencing and specific PCR of random samples," he continues the document, which also highlights that "
data are still very scarce to determine the true impact of the omicron variant
on the epidemiological characteristics of the infection, but preliminary studies point to greater transmissibility and greater immune escape. There is still a high level of uncertainty regarding possible changes in the severity of the cases ".
In the last 4 weeks analyzed by Health (from mid-November to mid-December) only 35 out of 2,127 sequenced random samples correspond to lineages other than those of the delta and omicron variants.
A person receives a vaccine against Covid at the Puerta de Hierro Hospital in Majadahonda (Madrid) .JAVIER BARBANCHO
According to estimates by the World Health Organization (WHO), the omicron variant has already been detected in
110 countries
and continues to spread exponentially, "doubling its cases in the communities where it is transmitted
in a matter of two or three days
."
Although the
profile of this variant
is not yet clear
, preliminary data show that it has a high transmission and reinfection capacity, although it also appears to have a lower capacity than its predecessors to cause severe disease.
South Africa was, on November 25, the first country to sound the alarm about this new variant that accumulates many more mutations than any of the previous 'versions' of SARS-CoV-2.
If compared with the first Wuhan viruses,
omicron
has 55 changes in its genome, 32 of them in protein S
, the
key used
by the pathogen to enter cells (15 of these mutations are precisely in the binding domain to the receiver).
Some of these mutations - such as N501Y, T95I, T478K or G142D - are old known;
they were already present in variants such as
alpha, beta or gamma
and have been associated with greater transmissibility or with greater ease in evading the immune response.
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Know more
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