A third dose suitable for children under 5 years old.
The Pfizer laboratory announced on Friday that it wanted to test a booster of anti-Covid vaccine in children of this age category, which could lead the company to file an application for authorization for three doses immediately next year at the little ones.
As part of ongoing clinical trials, the American pharmaceutical giant has selected a dosage of 3 micrograms per injection for children aged 6 months to less than 5 years.
This is ten times less than the dosage given to adults (30 micrograms), and also less than that of 5 to 11 year olds (10 micrograms).
A modified protocol
In children from 2 years to less than 5 years, a dosage of 10 micrograms indeed caused more fever than in the older groups, pushing the company to select a lower dosage.
But with two injections of 3 micrograms, their immune response was found to be poorer than that given to adolescents and young adults by the vaccine.
Pfizer has therefore decided to modify the protocol of its clinical trials, to include a third dose, injected "at least two months after the second", the company said in a press release (the first two remain injected 3 weeks apart. one from the other).
A booster dose has indeed shown, in older population categories, to increase the protection conferred.
No consequence on the calendar
This "adjustment" should not have any consequence on the anticipated schedule for the filing of an application for authorization for these young children, envisaged "in the second quarter of 2022", declared during a conference call Kathrin Jansen, person in charge of research for vaccines within the group.
Pfizer also announced Friday that it had started trials on 600 adolescents aged 12 to 17 to test a booster dose (of 10 or 30 micrograms).
Currently in the United States, in addition to adults, a booster dose is only permitted for adolescents 16 and 17 years of age.
Health
Vaccination in Ile-de-France: Where to vaccinate children from 5 to 11 years old?
Health
Coronavirus: For Macron, vaccination of children must be "desirable" but not mandatory
Omicron variant
Pfizer-BioNTech
Covid 19
Health
Coronavirus
Anti-covid vaccine
0 comment
0 share
Share on Messenger
Share on Facebook
Share on twitter
Share on Flipboard
Share on Pinterest
Share on Linkedin
Send by Mail
To safeguard
A fault ?
To print