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A British study on Friday revealed that a longer interval between doses of Pfizer's Covid-19 vaccine results in higher overall

antibody levels than a shorter interval

, although there is a sharp drop in antibody levels after the


first dose.

The study could help inform vaccination strategies against the

Delta variant

, which reduces the effectiveness of a first dose of the Covid-19 vaccine, although two doses are still protective.

"In the case of the longest dose interval ... the levels of neutralizing antibodies against the Delta variant were poorly induced after a single dose, and were not maintained during the interval before the second dose," the authors noted. study, led by the University of Oxford.

"After two doses of the vaccine, the neutralizing antibody levels were twice as high after the longest dosing interval compared to the shortest dosing interval."

Neutralizing antibodies

are believed to

play an important role in immunity

against coronavirus, but that's not all as T cells play a role as well.

The study found that overall T cell levels were 1.6 times lower with the long interval compared to the short 3-4 week dosing schedule, but that a higher proportion were "helper" T cells with the long interval. , which support long-term immune memory.

The authors noted that either dosing schedule produced a strong antibody and T-cell response in the

study of 503 healthcare workers


The results, published in preprint form, support the view that while

a second dose is necessary to provide full protection against Delta

, delaying that dose could provide longer-lasting immunity, albeit at the cost of short-term protection. term.

Last December,

Britain extended the interval between doses of the vaccine to 12 weeks

, although Pfizer cautioned that there was no evidence to support changing to a three-week interval.

Britain is

now recommending an 8-week interval

between vaccine doses to give more people high protection against the Delta more quickly, while maximizing the long-term immune response.

"I think 8 weeks is the sweet spot," Susanna Dunachie, joint lead investigator on the study, told reporters.

According to the criteria of The Trust Project

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