A global achievement for a young Egyptian doctor in New York..Alexandria graduate challenges the first killer
The young Egyptian doctor, Anis Hanna
A young Egyptian doctor named Anis Hanna, (28 years), achieved a global scientific achievement, as he reached with a scientific team at “Albert Einstein College” in New York, the genes controlling the healing of heart clots, the number one killer of humans around the world.
The major specialized scientific journals in the United States celebrated this achievement, which was achieved by the young Egyptian graduate from the Faculty of Medicine in Alexandria in 2017, and was also praised by the American Heart Association, the largest organization in this specialty in the world.
The doctor’s research, according to “Sky News”, is based on a main focus of his research, which is the discovery of the genes responsible for healing heart tissue damaged by clot, and he added: “Over 4 years of research, I discovered with a research group at Albert Einstein College of Medicine in New York the most important genes controlling inflammation and fibrosis. Myocardial infarction as a result of a stroke.
He pointed out that one of the most important genes that we discovered is the so-called “Smad3”, which is a very important gene in cytokine interactions, and this was proven in a study we published in Circulation Research, one of the most important journals in the field of heart research globally.
He continued, "We modified this gene in the cells that cause cardiac macrophages, as in experimental animals, and then subjected them to a heart attack, as happens in humans, and we discovered that this gene is responsible for activating these cells to remove the remains of the damaged part of the heart."
And he added: “After the work of these cells ends, this gene causes the inflammatory cells to mutate into cells that are useful in inhibiting inflammation and contributing to the healing of the heart muscle, in addition to protecting the muscle part adjacent to the clot from damage, and we have seen the effect of this genetic modification on heart functions, and indeed contributed to the survival of mice Experiments after the stroke, we found that this gene is responsible for a significant improvement in heart function and for reducing the death rate from stroke by less than half.”
The researcher said: “We use in our research a range of the latest technologies, many of which are available, but in a few places in the world, and some of them are designed specifically for our research. One of these complex techniques is performing microscopic open heart surgeries on experimental mice to cause a clot in the heart, which is a very precise technique that deals with blood vessels. Micrometric sizes in the heart, and another technology designed by myself and published in the Matrix Biology, which is the formation of tissue similar to clot tissue in the laboratory to study the behavior of cells and their response to gene therapy, and these and other techniques produce huge amounts of data, so we use artificial intelligence systems for our research group capable of analyzing information Within hours.”
He confirmed that his discovery with his team of the genes that control heart clot healing paves the way for gene therapy for this defect in humans.
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Anis Hanna,
Treating heart attacks