[Explanation] Recently, the adenoviral vector new crown vaccine jointly developed by the team of Chen Wei, an academician of the Chinese Academy of Engineering and Cansino Bio, has been approved by the State Food and Drug Administration and listed on conditional conditions.
On February 28, the Journal of the Chinese Medical Association held a media communication meeting on the vaccine in Beijing.
[Explanation] The adenovirus vector new crown vaccine adopts a single-dose immunization program and can be stored stably at a temperature between 2 and 8 degrees Celsius. The vaccination targets cover people aged 18 and over. These characteristics have attracted widespread public attention.
Feng Luzhao, a public health expert, introduced the characteristics of this vaccine.
[Concurrent] Feng Luzhao, Executive Deputy Dean of the School of Medicine and Public Health, Peking Union Medical College
Adenovirus vector vaccine, it should be said that its process principle is that it uses adenovirus as a vector that is equivalent to the effective component of the new coronavirus. It is chimeric together, but the adenovirus-related genes are deleted, so the adenovirus vector itself is in the body If it does not replicate, it will not cause adenovirus infection. At the same time, it is chimeric with the S protein (gene) of the new coronavirus.
To put it in a vivid way, the adenovirus vector is equivalent to a rocket. It transports satellites, such as S protein, to human cells to make it work.
[Explanation] Data analysis shows that in Pakistan's Phase III clinical trial, 28 days after a single injection of adenovirus vector vaccine, the protective effect of severe cases of new coronary disease reached 100%, and the overall protective effect was 74.8%.
[Concurrent] Yu Xuefeng, Chairman of Cansino Biological Co., Ltd.
At present, the age at which we use the vaccine, that is, those under 18 years old. We are currently (not sure). In fact, our clinical phase II is discussing (right) the immunogenicity of vaccines in people aged 6-18 years, but the data Haven't got it yet.
[Explanation] Regarding the durability of the new crown vaccine and how long it can last, Feng Luzhao believes that the current new crown vaccination has not been launched for long, and it takes time to continue to observe.
[Concurrent] Feng Luzhao, Executive Deputy Dean of the School of Medicine and Public Health, Peking Union Medical College
How long is it protected?
In fact, there is no final conclusion.
Because the latest vaccination was the first one to be marketed, and it has been a few months now. I have not seen a drop in its antibody level or its protection rate.
[Explanation] As for whether the virus mutation has an impact on the vaccine, Feng Luzhao pointed out that the key to virus mutation depends on whether it mutates at key points.
[Concurrent] Feng Luzhao, Executive Deputy Dean of the School of Medicine and Public Health, Peking Union Medical College
Mutation is like we change clothes every day. Changing clothes will not affect my recognition of you, but if you have a plastic surgery, it happens to be a particularly critical point. You have changed particularly important facial features. Particularly important mutations will definitely affect the characteristics of this virus and affect the effectiveness of the vaccine.
[Explanation] In this regard, Yu Xuefeng said that for most of the current strains, the protective effect provided by the new crown vaccine is not much different, even if the key points are changed, which affects the effect of the existing vaccine, the current new crown vaccine The level of production technology can be updated quickly.
[Concurrent] Yu Xuefeng, Chairman of Cansino Biological Co., Ltd.
For example, if we find that the protection is not enough, if we re-synthesize the S protein gene sequence and install it into a new adenovirus vector, a new virus species should be formed soon, so we will do it soon. The immunogenicity evaluation of the product can be quickly bridged to the existing production technology.
Reporter Wen Mengxin and Li Chun reporting from Beijing
Editor in charge: [Wang Sishuo]