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Researchers at the University of Oxford have published in
The Lancet Preprints
an analysis of
additional data from ongoing trials of their Covid-19 vaccine
, developed jointly with the pharmaceutical company AstraZeneca.
In addition, the authors give the first clues about the potential of the vaccine to reduce the transmission of the coronavirus: They have observed
a 67 percent reduction in infections
after the first dose in volunteers from their trials in the United Kingdom.
These data are important because, to date, many data have been published on the effectiveness of vaccines in preventing the disease,
but it is still unknown whether they prevent vaccinated people from being infected and contagious in an asymptomatic way.
76% effective from 22 days
On the other hand, in their work they reveal that the efficacy of the vaccine is greater at longer booster intervals, and that a single dose of the vaccine is
76 percent effective from 22 to 90 days
after vaccination.
In this pre-print, which is currently under review by
The Lancet
, they report on an analysis of additional data to include trial information up to December 7, 2020,
which includes a further 201 cases of primary symptomatic Covid-19
(332 cases out of the 131 previously notified).
Thus, they point out that the effect of the dosing interval on efficacy is pronounced, with the efficacy of the vaccine increasing from 54.9 percent with an interval of less than six weeks to 82.4 percent when 12 or more are separated. weeks.
They also detail that a single standard dose of the vaccine is 76 percent effective in protecting against symptomatic Covid-19 during the first 90 days after vaccination, once the immune system has created this protection 22 days after vaccination,
and protection shows little sign of decline in this period.
"Important verification of preliminary data"
"These new data provide important verification of the interim data that was used by more than 25 regulators to grant authorization for the emergency use of the vaccine.
They also support the recommendation to adopt a 12-week booster interval
, as they seek the optimal approach to deployment, and ensures that people are protected from 22 days after a single dose of the vaccine, "said the head of the trials, Professor Andrew Pollard.
Thus, the analyzes presented in this work suggest that it is the dosage interval and not the dosage level that has a great impact on the efficacy of the vaccine.
"This is in line with previous research
supporting greater efficacy with longer priming intervals performed with other vaccines such as influenza, Ebola, and malaria," says Pollard.
The researchers hope to publish data regarding the efficacy of their vaccine in the new virus variants "in the next few days", and they expect the results to be
"very similar to those already reported by other vaccine developers."
According to the criteria of The Trust Project
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