A unique genetic mutation has been discovered that protects against potentially life-threatening diseases

A recent study conducted by some researchers at McMaster University, the Montreal Institute for Clinical Research and the University of Montreal, revealed that the mutated gene mainly in the liver lowers harmful plasma cholesterol and prevents cardiovascular disease, which prevents life-threatening diseases.

Researchers at McMaster University, the Montreal Institute for Clinical Research and the University of Montreal believe they have found a fountain of youth.

Scientists said that the gene protects against other human diseases, especially liver diseases.

This could allow people who are fortunate to remain healthy and live longer, the researchers say.

Montreal scientists found that in addition to a low level of harmful plasma cholesterol and a lower risk of cardiovascular disease, liver function is completely normal when measured through imaging and a full medical evaluation, during the study on a number of people.

In the new study, McMaster researchers showed that the overexpression of this gene variant in the livers of mice that did not carry PCSK9Q152H had a surprising protective effect against injury and liver dysfunction.

In addition, overexpression significantly reduced circulating PCSK9 levels, just as it does in people, which reduces bad cholesterol in individuals and maintains cardiovascular health.

The McMaster scientists went on to show that the gene variant PCSK9Q152H acts as a unique co-protein to stabilize many of the well-known endoplasmic reticulum (ER) companions, namely GRP78 and GRP94, and to increase their protective activity against liver damage.

“These results are particularly satisfactory because they demonstrate empirically that this genetic mutation, known to reduce cardiovascular events, also protects against liver injury and dysfunction, even in individuals in the late 1980s and mid 1990s,” said Chretien, a emeritus scientist at the Ottawa Hospital Research Institute. Age. Moreover, these results should allow us to determine whether this unique mutation provides additional protection against liver diseases such as cancer, in addition to its protective effect against cardiovascular accidents. "