[Explanation] The Third Affiliated Hospital of Guangzhou Medical University released news on June 10 that the team of associate professor An Geng of the reproductive medicine center of this hospital used "stem cells + 3D printing technology" to effectively repair the defective rabbit corpus cavernosum and restore its penile erection and ejaculation. Function and complete the childbirth. The research results were published in the international journal Nature.
An Geng introduced that the penis is an important part of the male reproductive system, and the "penile cavernous body" in the penis is a prerequisite for maintaining normal penile erection and urinary function. However, a variety of congenital developmental abnormalities, tumors or trauma can cause penile deformities or penile cavernous defects, which seriously affects sexual and reproductive functions.
[Same period] An Geng, Associate Professor, Center for Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University
We know that the construction of male external genitals, the most important are two, that is, the entire stent acts to maintain this shape of the short corpus cavernosum, and part of it is the urethral corpus cavernosum, which is used to complete urethral repair, but the main reproductive function still needs to be Erectile function, ejaculation, etc. can only be accomplished by the function of the penile cavernous body, so the purpose of completing this work is to first restore the body of the short penile cavernous body.
[Commentary] An Geng, together with Professor Shi Xuetao of South China University of Technology and Professor Mao Chuanbin of the University of Oklahoma, USA, jointly studied the construction of a bionic 3D printed hydrogel scaffold with a multi-scale porous structure, which is structurally and mechanically matched to natural sponges Biological material.
[Same period] An Geng, Associate Professor, Center for Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University
The process of the whole experiment is still relatively complicated. First of all, we will do a digital treatment of the entire penis system. First of all, we need to look at some experimental techniques. The organizational structure of the entire sponge body, the size of its gaps, its toughness, And its strength. After making these parameters, we can carry out the research and development of the entire material science. According to the research and development of these materials science, and then as close as possible to the relevant parameters of the sponge in the natural state, after it is reached, we can pass 3D Printing method to complete the printing of the entire bracket.
[Explanation] Subsequently, the researchers implanted this "bioengineered vascularized penis corpus cavernosum" into a male rabbit with a cavernous defect, and mixed the male and female rabbits undergoing repair of the injury and delivered them continuously within 4 months. The bunny confirmed that it restored its physiological function and reproductive ability and completed the offspring.
[Same period] An Geng, Associate Professor, Center for Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University
Now all the work of optimizing all the materials, including the construction of animal models has been gradually resumed. I estimate that in the next two years, we will complete the repair of the damage of this primate monkey (cavernous body), and then after this work is completed, Then below we may want to carry out clinical transformation.
(Reporter Cai Minjie Wei Jiefu Guangdong reported)
Editor in charge: [Liu Xian]