Cheng Yuan, who lives in Shijiazhuang, Hebei, went out for the first time this year. He took a high-speed train to Beijing in order to get a shot of rabies vaccine.

  Cheng Yuan's case is not a case. Recently, rabies vaccines in Hebei, Shanxi, Shaanxi, Yunnan and other places have been "out of stock". Many people have traveled to nearby counties and cities to inquire about vaccination sites. The rabies vaccine is "unavailable". Vaccine emergency" notification.

  In this case, the health department called for strengthening animal management, applying for certificates in accordance with the relevant provisions on canine epidemic prevention, and regularly injecting veterinary rabies vaccines for dogs to establish a dog immune barrier.

On June 6, the Shijiazhuang CDC issued an announcement saying that the supply of rabies vaccine was tight. Screenshot

Public cross-city, cross-province rabies vaccine

  On the evening of May 26, Cheng Yuan was scratched by his cat. Cheng Yuan said that although the cat had received anthelmintics and had been vaccinated, she was still not sure that she needed a rabies vaccine.

  On the same day, she consulted several vaccination sites near her home and found that there was no rabies vaccine. "I asked every county from the city and said that the vaccine was out of stock." After finding the vaccine for a whole day, Cheng Yuan called Asked the hospital in Beijing, the other party replied "can be called." Early on the morning of the 27th, Cheng Yuan took the high-speed rail to Beijing and received the first shot of the rabies vaccine. Four days later, he went to Beijing and received the second shot.

  In Hengshui, Hebei, Liu Yuan’s 14-year-old daughter was bitten by a dog. In order to ensure that her daughter was vaccinated against rabies within 24 hours, Liu Yuan and her lover drove to Tianjin overnight and only “chased” a shot.

  The situation is not unique to Hebei.

  The Beijing News reporter combed public reports and Weibo help information and found that in recent days, Yunnan, Shanxi, Shaanxi, Shandong and other places have experienced shortages of rabies vaccines.

  Qiao Xin of Lantian County, Shaanxi Province told the Beijing News reporter that he was bitten by a dog in his hometown on May 2 and first received the first dose of rabies vaccine in the county. From the second injection, there was no vaccine to be given in his hometown. He had to drive for more than 2 hours to get an injection in downtown Xi'an. At the time of his fourth shot in early June, he found nearly 10 inoculation spots before successfully hitting the fourth shot.

  On May 29, a staff member of the Handan City Center for Disease Control in Hebei said, "It is almost difficult to find rabies vaccines throughout the city." Citizens need to contact the vaccination site on their own. "One by one, I am completely lucky."

  The staff at a vaccination site in Xi'an, Shaanxi also confirmed that the vaccine "out of stock" has allowed many people in need of vaccination to find seedlings across districts and provinces.

Multiple notices of "rare vaccine shortage"

  On June 2nd, according to the official vaccination sites announced by the Shijiazhuang CDC, reporters from the Beijing News contacted more than a dozen schools including Shijiazhuang City, Xinle City, Zhao County, Wuji County, Gaoyi County, Zhengding County, etc. The telephone numbers of the vaccination units were informed that the rabies vaccine was out of stock. The best vaccination site, rabies vaccine has also been "out of stock" from a week ago.

  Among them, a staff member of the Center for Disease Control of Zhao County said that there was no rabies vaccine available from the beginning of the Spring Festival, and citizens in need could only go to the surrounding counties and cities to inquire. The staff at another vaccination site said that the vaccine was deployed by the superior department, and a small amount of vaccine will be delivered from time to time, but it is far from enough to meet the people waiting in line to be vaccinated.

  The hotline staff of Shijiazhuang 12320 Health Bureau said that the similar situation has lasted for more than half a month, and there are many calls for rabies vaccine consultation every day. "In the past few days, there have been thousands of (calls) every day, Handan and Xingtai. , All come to ask." It said that the current rabies vaccine is in a "national out-of-stock state", and recommended that patients call the vaccination point one by one for consultation.

  In this regard, the Shijiazhuang CDC also issued a document on June 6 stating that the supply of human rabies vaccine cannot be effectively alleviated in the short term, and some districts and counties are still out of stock. Many rabies vaccination clinics cannot provide vaccination services normally. The Center for Disease Control requires all districts and counties to designate one or two vaccination clinics to be responsible for vaccination of rabies vaccines, and do a good job of ensuring supply.

  Subsequently, according to the vaccination telephone announced by the Xi'an CDC of Shaanxi, the reporter of the Beijing News continuously consulted nearly 10 vaccination sites in Xi'an Fengcheng Hospital, Ordnance Industry 521 Hospital, Shaanxi Provincial Communications Hospital, among which 9 were vaccinated. Points are "out of stock". Only the staff of Yanta District Traditional Chinese Medicine Hospital said that they can be vaccinated against rabies, but the existing rabies vaccine has just been transferred and the stock is not large. If the vaccines from different manufacturers were vaccinated in the previous few times, you need to ask other vaccination sites.

  In addition, Henan Pingdingshan City, Shanxi Taiyuan City and other disease control centers directly issued a notice of "abnormal shortage of rabies vaccine" to remind citizens to keep dogs civilized.

  Staff at a vaccination site in Taiyuan, Shanxi Province, told the Beijing News reporter that the vaccination site where they had been "out of stock" since the end of 2019. Since April this year, the shortage of rabies vaccine has increased.

Decrease of production enterprises leads to decrease of total market capacity

  Why is there a shortage of rabies vaccine?

  The Hengshui City Health and Health Commission of Hebei replied to the public on June 1 that the vaccine cut-off was caused by insufficient production capacity of rabies vaccine manufacturers and the impact of the new crown epidemic.

  On June 7, the staff of the Hebei Provincial Center for Disease Control responded to a reporter from the Beijing News that, overall, the rabies vaccine currently purchased in Hebei Province can basically meet the public's demand for vaccination, but is in a tight supply situation.

  The quantity of vaccines purchased is not balanced across the country. "Some places are more, some are less. If there is no vaccine, it is not convenient to go to a nearby place for vaccination." The above-mentioned staff said that the current disease control in Hebei Province is actively coordinating Manufacturers, to increase the supply of vaccines, on the basis of efforts to meet public vaccination needs, to facilitate public vaccination.

  The Hebei Provincial Center for Disease Control and Prevention also reminded citizens to apply for documents in accordance with the relevant regulations on canine epidemic prevention, and regularly inject veterinary rabies vaccines for dogs to establish a dog immune barrier. Individuals should pay attention to protect themselves and their families from scratches and bites.

  Regarding the "out of stock" situation of the rabies vaccine, the reporter contacted several rabies vaccine manufacturers on June 5.

  A staff member of the sales department of Liaoning Chengda Biological Co., Ltd. introduced that the company's output has not decreased. At present, the market is generally in a state of vaccine shortage. "Our company's production has been stable. The disease control departments and drug supervision departments of various provinces and cities have passed Bidding to decide whether to purchase our vaccine, and then we will distribute the goods."

  Lin Wei works for another domestic manufacturer of rabies vaccines. He has been in the business for over 10 years and is currently the head of regional sales. He said that in recent years, vaccine companies have been shuffled under the same strict quality control as Dalang Taosha, and now there are only 7 companies with rabies vaccine production qualifications nationwide. Including his company, the output of all enterprises has not decreased. On the contrary, since 2018, continuous improvement of technology to improve production, but it is still difficult to fill the total shortage caused by the reduction of production enterprises. "It can be said that before the second half of 2019, stocks were being consumed in various places. Later, the stocks bottomed out, and the new drug amount could not meet the market demand, and there was a stock out."

  Such a situation is not without warning. Lin Wei said that the total production capacity could not keep up with the speed of medication, and the inventory was getting less and less. At that time, he had the worry of being out of stock. "The epidemic has reduced people’s outbound and flow, which has suppressed the demand for vaccines to a certain extent, but now it has been 6 The peak season for rabies vaccine demand came this month."

  An immunology expert from a Beijing university, who declined to be named, told the Beijing News that foreign rabies vaccines do not meet China's standards and cannot enter China's vaccine market as a supplement. Therefore, one way to deal with the current vaccine dilemma is to avoid If there are hidden dangers in contact with animals, the breeder should also strengthen the management of the animals.

  He reminded that rabies is indeed a disease with a very high fatality rate after infection. There should be no fluke, and you must find a vaccine as soon as possible.

  According to the risk of rabies after injury, the injured animals are divided into three types: high risk, low risk and no risk. High-risk animals such as dogs, cats, bats, etc. Low-risk animals such as cattle, sheep, horses, pigs and other domestic animals, rabbits, rodents and other rodents. Non-risk animals, ie all animals other than mammals, do not transmit rabies, such as turtles, fish, birds, etc. After being injured by them, there is no risk of exposure, and there is no need to deal with rabies after exposure.

  In addition, from a long-term perspective, the above experts believe that it is more necessary for the agricultural sector to strengthen the production and management of animal rabies vaccines, "Improving the immunity of animals after vaccination and reducing the use of human vaccines is the most ideal status."

  Cheng Yuan, Liu Yuan, Qiao Xin, Lin Wei are all pseudonyms

  Beijing News reporter Zhang Jingshu