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People with cancer who get Covid-19 have a crude death rate of 13%, according to the largest series of data published so far from a multinational perspective, which also revealed cancer factors related to increased mortality.

The Lancet publishes this Friday the first report of the international initiative of the Covid-19 and Cancer Consortium (CCC19) to monitor the results within this vulnerable population.

The data in this first CCC19 report was obtained from 928 patients from Spain, Canada and the United States.

People with cancer "face great uncertainty in the Covid-19 era, including whether the balance of risk and benefit in cancer treatment has changed in any fundamental way," said Jeremy Warner of Vanderbilt University. and one of the study authors.

The mortality rate for this group of patients as a whole was 13%, "more than double that reported for all COVID-19 patients ," Warner added.

In addition, certain subgroups, such as those of active cancer patients and those with impaired status, performed "much worse", Warner added in a statement from Vancerbilt University.

Initial data "did not show any statistical association between 30-day mortality and cancer treatments, suggesting that surgery, adjuvant chemotherapy, and maintenance chemotherapy could continue during the pandemic with extreme caution."

While older patients and those with significant comorbidities have "a substantially increased risk of dying from Covid-19," our early findings are encouraging news for patients without significant medical conditions receiving their cancer therapy within four weeks of the infection, "said Nicole Kuderer, also a study author.

Kuderer of the Seattle Advanced Cancer Research Group, however, said more data is needed to reliably assess the highest-risk individual therapies.

Cancer-specific factors associated with increased mortality included having a score of two or more on the ECOG scale, a rating that measures how that disease impacts a patient's abilities for daily life.

A state two designates a patient who is able to take care of his own needs, but who cannot work and has symptoms that force him to stay in bed for several hours a day, in addition to those at night, but who do not they exceed 50% of the day.

Another factor associated with increased mortality was having an active cancer status, particularly progressive cancer, the statement said.

Mortality risk also increased with the number of comorbidities, such as hypertension or diabetes, "particularly with two or more comorbidities."

As in the case of the non-cancer population , mortality increased with age. This was 6% for cancer patients younger than 65 years.

It was 11% for those between 65 and 74 years old and 25% for those over 75 years old. Additionally, men had a higher mortality rate than women, 17% vs. 9%.

The initial CCC19 report defines some of the main risk factors and outcomes for certain patient groups, and other projects are being carried out within this initiative to further expand this knowledge.

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