French championship specialist Rafael Nadal was drawn to face Egor Gerasimov, from Belarus, in the first round.
Rebecca Peterson, ranked 49, will face the Belgian Alison van Uytvanck, ranked 64, in the ladies' singles tournament.
Six of the top ten are missing
Earlier on Thursday, big brother Elias Ymer went out of the qualifiers for the grand slam tournament, when he lost to the Austrian Sebastian Ofner.
In connection with the draw, the organizers also announced that the ladies' world track Belinda Bencic, Switzerland, has withdrawn from the tournament.
Thus, six of the ten best-ranked ladies in the tournament are missing, including world number one and reigning champion Ash Barty.
Start on Sunday
Milos Raonic, number 20 in the men's world rankings, also made a late rebid.
The first round starts on Sunday.
ARCHIVE: Scandal in the US Open - Novak Djokovic discarded (September 7, 2020)
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Novak Djokovic apologizes after hitting a linebacker on the larynx after a lost game.
Photo: TT