Make China's contribution to achieving vaccine accessibility
——Remember Sinopharm Group China Biological Research Team
□ Our reporter Wu Jiajia
On June 1, the first batch of the COVAX (New Coronary Pneumonia Vaccine Implementation Plan) covid-19 vaccine led by the WHO was off the assembly line by the Beijing Institute of Biological Products of Sinopharm Group. This is also the first batch of China’s covid-19 vaccine supplied with COVAX... China’s accessibility and affordability make China’s contribution, and Sinopharm Sino Biotech is an important force.
Among all 15 disease vaccines in the National Immunization Program, China Biological is responsible for 80% of the supply tasks and is the "national team" and "main force" of my country's biological products.
At the beginning of the epidemic, China Biosciences established a scientific research team to simultaneously promote the five vaccine research and development technical routes deployed by the country, and focused on inactivated vaccines and genetically engineered vaccines.
The most worrying thing about vaccine research and development is time. In the past, vaccine research and development had a pattern, "it took 10 years and cost 1 billion yuan."
However, the epidemic situation is severe, and every minute must be raced against.
Under the condition that the process remains unchanged, the standard remains unchanged, and the data is not saved, the R&D team creatively changed the process from series to parallel in the past. Animal species and various experiments are carried out in parallel, which greatly accelerates the speed of research and development.
The development of the new crown vaccine requires close contact with the virus, and related experiments can only be carried out in specific laboratories.
In order to ensure that the laboratory virus does not flow out of the air, the laboratory is in a negative pressure environment. If a person is in a negative pressure and a normal environment for a long time, it will affect lung function, reduce the oxygen content in the blood, and then affect the vitality of the brain, and even cause the body The function of various organs is reduced due to pressure changes.
But the epidemic is raging, and the progress of vaccine research and development must be as fast as possible.
In order to speed up the progress of research and development, the daily working hours of scientific research personnel greatly exceed the 4 hours stipulated by the laboratory.
Researchers work on an average of about 19 hours a day. Many people do not go home for a long time and can only leave messages and exchanges with their children on their mobile phones late at night. They have become "cloud parents" in the eyes of children.
In just 98 days, on April 12, 2020, the new crown virus inactivated vaccine obtained the world's first clinical trial approval for the new crown virus inactivated vaccine.
The results of the blind review of the Phase I and Phase II clinical trials and the phased unblinding showed that the safety after vaccination was good, and there was no serious adverse reaction; after different procedures and different doses of vaccination, the vaccinated persons all produced high-titer antibodies.
The third phase of the vaccine clinical trial is the most invested and most difficult test. It mainly adopts a random blind controlled trial with sufficient sample size to further verify the effectiveness and safety of the vaccine, and finally provide a sufficient basis for the review of the registration application.
The epidemic situation in my country has been effectively controlled, so tests can only be carried out in foreign epidemic areas.
In early July, China Biosciences selected experts from clinical trials to form the "Great Wall" project team, and went to the UAE, Bahrain, Egypt, Morocco, Argentina, Peru and other countries to carry out Phase III clinical trials of the new crown inactivated vaccine.
In the high-risk environment in the epidemic area deep in clinical trials, there is a high probability of direct contact with infected persons.
The predecessor of the vaccination site in Abu Dhabi, UAE is the largest shelter hospital in the area, and the venue that is connected to the vaccination site in Bahrain is even the site of the new crown pneumonia shelter hospital.
These dangers did not deter the members of the Great Wall project team. 18 party members set an example and drove other colleagues to go all out.
During the Phase III clinical trial, 7 comrades successively applied to join the party, and 3 comrades with excellent performance joined the party.
With the support of the branch and everyone’s efforts, the project team completed the first 10,000 vaccination in 24 days, the second 10,000 vaccination took 10 days, and the third 10,000 vaccination took only 6 days, setting a record for the number of people enrolled in the group and their country. The number one in the world such as other quantity.
On December 9, 2020, China's new biological new crown inactivated vaccine was officially registered and marketed in the UAE, becoming the world's first vaccine officially approved for marketing. It has been vaccinated in more than 70 countries and regions around the world.
On May 7 this year, the World Health Organization announced that the new crown inactivated vaccine of Beijing Institute of Biological Products of China has obtained emergency use certification. This is the sixth vaccine in the world to receive emergency use certification and the first vaccine developed by a developing country. WHO emergency use certification.
China's vaccines can stand on the same starting line as developed countries in Europe and America, demonstrating Chinese technology, Chinese manufacturing, Chinese brands and China's role.
"In the national battle against the'epidemic', China Biosciences fulfilled the responsibility of a central enterprise to protect the lives and health of the people. The epidemic has not ended, and the struggle cannot be stopped. We must provide more high-quality vaccines to benefit the people of the country and contribute to the world." Party Secretary Zhu Jingjin said.
——Remember Sinopharm Group China Biological Research Team