Shanghai Light Source illuminates the door of microcosm science

  In a building resembling a "Nautilus" in Zhangjiang Science City, light seemed to have stopped.

The Shanghai Synchrotron Radiation Light Source (hereinafter referred to as Shanghai Light Source) produces wide-band synchrotron radiation, which is used by cutting-edge scientific research teams around the world every day.

Construction started in December 2004 and opened to users on May 6, 2009. The rise of this scientific landmark has enabled China to join the world’s third-generation synchrotron radiation light source device with the least investment and fastest construction speed of similar devices. The first line.

  As of July 2020, Shanghai Light Source has completed more than 14,000 experimental projects that have passed expert review, and served 30,308 researchers from 3,116 research groups in 575 units across the country. It has become the largest science in my country with the most users and results. Device.

  "Nautilus" hatches scientific research crystals

  Shanghai Light Source allows us to "see" the inner structure of matter, understand the laws of atomic and molecular motion, and illuminate the door to science in the microcosm.

This beam of light is the "dream light" that shines into the future of science in the minds of many Chinese scientists.

  With the emergence of Shanghai Light Source, analysis work that could not be done or needed to go abroad to be queued can be completed at the "door of home".

With the help of Shanghai Light Source, Chinese scientists discovered Weil fermions through experiments, proposed and verified the mechanism of single-atom catalysis, observed the structure of rat alveoli for the first time in the world, and analyzed avian influenza, Ebola, Zika and Kikong The protein structure of a series of viruses such as Kenya fever and the new coronavirus has explained the transmission mechanism.

During the ten years of operation of Shanghai Light Source, the number of protein crystal structures analyzed by domestic devices increased from 99 to 5,076.

  More than 30 drug research and development companies carry out research and development work at the Shanghai Light Source's biological macromolecular crystallography line station.

This site provides a structure-based new drug development method for domestic drug research and development companies.

Compared with traditional methods, structure-based research and development methods are more efficient and accurate. The first successfully marketed drug only took 6 years, which has promoted the research and development of new drugs in Shanghai and surrounding areas.

  Super steel with both strength and ductility, a new generation of high-strength and high-conductivity copper-chromium-zirconium alloy contact wire used in the Beijing-Shanghai high-speed rail, a new structural molecular sieve material developed by the Sinopec research team, and the first anti-corrosion certified by the U.S. FDA and China Food and Drug Administration The new cancer drug "Zebutinib", the world's first spinning-grade single-layer graphene oxide, and single-atom catalysis are moving from theory to industrialization... With the support of Shanghai Light Source, substantial breakthroughs have been made in key technologies in emerging strategic industries.

  In the past ten years, Shanghai Light Source has produced a number of world-influential scientific research results in many fields, and has also made important breakthroughs in structural biology, condensed matter physics, chemistry, materials science, environment and medicine.

  Promote the construction of photonic large scientific equipment cluster

  Behind the high output is the result of Shanghai Light Source's consistent benchmarking with world-class equipment.

From the beginning, the operating rate, mean time to repair, and output rate of results were "hard indicators".

Over the past ten years, the device has been operating stably and efficiently, and its performance has been continuously improved. These "hard indicators" are at the international advanced level of similar devices.

Shanghai Light Source is also unremittingly carrying out key technology research and development and experimental methodological development. From the initial 7 lines and 7 stations with about 10 experimental methods, to today’s 17 lines and 21 stations with more than 100 experimental methods, the performance level of the device has been improved. Experimental ability.

  A world-class photonic large scientific device cluster is emerging in Zhangjiang.

Taking Shanghai Light Source as a starting point, it will form a photonic science center with important international influence with large scientific equipment clusters such as the soft X-ray free electron laser device, the hard X-ray free electron laser device and the ultra-strong and ultra-short laser device under construction. my country's technological innovation breakthroughs and leapfrog development.

  The fourth-generation synchrotron radiation source has been turned on.

Facing new development opportunities, Zhao Zhentang, director of the Shanghai Light Source Science Center, said: "The next ten years will be the opening period of Shanghai Light Source's golden operation. Shanghai Light Source will continue to produce major achievements, cultivate backbone talents for synchrotron radiation, and develop a new generation of synchrotron radiation light sources. Left behind."

  At present, the construction of the second phase of Shanghai Light Source is stepping up. It is estimated that by 2022, Shanghai Light Source will have 35 beam lines and 50 experimental stations put into operation. By then, nearly 10,000 scientific researchers will carry out basic, application and development on the device every year. the study.

After Shanghai Light Source Phase II was completed and put into operation, its microstructure detection capability was in the forefront of the international advanced third-generation synchrotron radiation device, and it is also the most internationally competitive synchrotron radiation source in my country in the next 5-7 years.

  Wang Xiaojiao, reporter Wang Chun