The meeting took place in Naples and ended with a score of 2: 0.
In the 41st minute, the hosts brought forward Armando Anastasio's own goal, and on the 75th the Neapolitans' advantage was doubled by Irwin Lozano.
"Napoli" scored nine points and topped the standings of Group F. "Rijeka" closes the quartet without gaining a single point.
Earlier Tottenham defeated Ludogorets in the Europa League match.