The meeting ended with a score of 7: 5, 6: 1, 3: 6, 6: 1 in favor of Rublev.
The match lasted 2 hours and 12 minutes.
In the next round of competitions, the Russian tennis player will play against the winner of the confrontation between Serb Dusan Lajovic and South African representative Kevin Anderson.
Earlier, Djokovic defeated Berankis in three sets at Roland Garros.