The modern science and technology blessing traditional Chinese medicine project led by Zhang Boli won a big award-the
development of traditional Chinese medicine from "a needle in a haystack" to "a needle in a bowl"
Focus on the frontline of science and technology
"Clinical research, treatment of Chinese and Western medicines, research and development of new drugs, screening of old drugs, etc. are inseparable from technological support." At the award ceremony of Tianjin Science and Technology "Oscar" on April 23, Zhang Boli, academician of the Chinese Academy of Engineering and president of Tianjin University of Traditional Chinese Medicine, expressed emotion Say. Academician Zhang Boli led the "New Coronary Pneumonia Integrated Traditional Chinese and Western Medicine Treatment and Innovative Chinese Medicine Xuanfei Baidu Granule Research" won the first prize of Tianjin Special Award for Fighting New Coronary Pneumonia. The Xuanfei Baidu prescription developed by the academician Zhang Boli team was selected as the "three medicines and three prescriptions" recommended by the state and has been widely promoted and applied. Modern science and technology combined with traditional Chinese medicine experience has changed the development process of new drugs from "needle in a haystack" to "needle in a bowl".
Long-distance Information Technology Helps TCM Syndrome Investigation
Academician Zhang Boli said that with the help of remote information technology to connect the front and the rear, collaboratively carry out case data processing and basic research, and completed the first multi-center large sample new coronary pneumonia TCM syndrome epidemiological investigation and research.
"When New Coronary Pneumonia first appeared, Western medicine and Chinese medicine knew very little about it." Zhang Junhua, director of the Evidence-Based Medicine Center of Tianjin University of Traditional Chinese Medicine, introduced that Western medicine mainly recognizes viruses through gene sequencing, and Chinese medicine focuses on the clinical manifestations of patients. To understand the syndromes and determine the etiology and pathogenesis, it is necessary to differentiate syndromes and treat prescriptions. Therefore, after arriving in Wuhan on January 27, Academician Zhang Boli arranged tasks for the project team to develop a clinical data collection system to prepare for the syndrome investigation.
"We have previous experience in the development of clinical data collection systems, and this time the biggest challenge is that the time is too tight. In addition, because the front-line medical personnel wear isolation suits, this system should also be suitable for operation under closed isolation conditions." Zhang Junhua introduced, eventually It took them less than a week to develop a clinical data system App that allows doctors to complete data collection and return via mobile phones. In order to avoid a large number of concurrency caused by system load problems, the project team contacted the National Supercomputing Tianjin Center, they specially prepared 20 servers for unexpected needs.
Through the syndrome collection system App, the project team conducted a TCM syndrome survey on more than 1,000 patients with new coronary pneumonia, and clarified the characteristics and etiology and pathogenesis of the "humid toxin epidemic" TCM syndrome, guiding the direction of clinical treatment and guidelines.
Data analysis technology helps traditional Chinese medicine
"The realization of the syndrome is followed by treatment, and the data of the changes in the condition should be fed back in time." Zhang Junhua said that it is very important to choose which information is collected to best reflect the changes in the disease. Many clinical research programs have been registered in early February, but evaluation There are more than 100 indicators, such as fever reduction, symptom reduction, nucleic acid negative, inflammatory factors, CT image absorption ... It is difficult to choose.
After 8 years of practice, the evidence-based medicine team of Tianjin University of Traditional Chinese Medicine has established a set of technical processes that meet international standards. Faced with the problem of evaluation indexes of new coronary pneumonia, they carried out emergency research. In order to obtain expert consensus, academicians Zhang Boli and other dozens of first-line treatment experts participated in the selection of the core index set, and finally formed the first core index of new coronary pneumonia clinical evaluation Set (COS-COVID). This achievement was highly praised by the World Health Organization New Coronary Pneumonia Characteristics Research Group.
Through the analysis of clinical data of more than 2,000 cases in different stages of designated hospitals, sheltered hospitals and isolation points, the system summarizes the characteristics and advantages of traditional Chinese medicine treatment, and effectively guides the scientific treatment of comprehensive intervention and targeted intervention of traditional Chinese medicine, especially for severely ill patients On the basis of modern medical support treatment, traditional Chinese medicine can also be seen to be split.
Traditional Chinese medicine components + traditional experience to accelerate the development of new drugs
"It is determined that this disease is a" wet poison epidemic "in Chinese medicine. We have optimized it according to clinical characteristics based on four classic prescriptions through literature research and clinical experience." Wang Tao, deputy director of the Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine After the introduction, they carried out pharmaceutical research and conducted chemical composition analysis to basically clarify the main chemical ingredients in the prescription. Then through multidisciplinary cross-activity evaluation, part of the mechanism of this compound treatment of new coronary pneumonia.
"The rapid development of new drugs in an emergency state is inseparable from our years of accumulation." Wang Tao said, "Academician Zhang Boli has always emphasized that we should conduct in-depth research around the" two relatively clear "of drug substances and mechanisms of action. Improve the scientific and technological level of traditional Chinese medicine. We started conducting component traditional Chinese medicine research 20 years ago and constructed a component library of traditional Chinese medicine. We can provide corresponding active components according to clinical needs. "Currently in the component library of the Institute of Traditional Chinese Medicine , 60,000 Chinese medicine components have been stored.
"Although it is supported by modern scientific and technological means, if there is no TCM theory and experience guidance, we will select suitable Chinese medicines one by one and it will be like" a needle in a haystack. "With the guidance of Chinese medicine experience, this process will become a" needle in a bowl " The success rate has been greatly improved. "Zhang Junhua said with emotion, they also explored a path for the discovery of new Chinese medicines in an emergency. The most fundamental thing is to combine traditional Chinese medicine experience with modern scientific and technological means.
As Academician Zhang Boli said, TCM, as a treasure of ancient Chinese science, played an important role in the entire anti-epidemic process. From the past participants to the main force, integrated Chinese and Western medicine treatment has also become the highlight of the Chinese plan. "This also strengthens our confidence and determination to explore the scientific connotation of traditional Chinese medicine through scientific and technological innovation, promote the inheritance and innovation of traditional Chinese medicine, and realize the revitalization and development of traditional Chinese medicine."