Long-term chloroquine does not protect against severe cases of Covid-19

They take chloroquine or hydroxychloroquine "for the long haul" especially for autoimmune diseases. However, his patients were no less affected by severe forms of Covid-19 during the epidemic, according to a French study published Tuesday.

This work was carried out by Epi-flagship, a structure bringing together the Medicines Agency (ANSM) and Health Insurance, based on the latter's data (in particular reimbursement of medicines) and hospital medical records (dates d (hospitalization, diagnostics, medical procedures and medicines delivered ...).

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The study, conducted on nearly 55,000 patients, "does not suggest a preventive role for the use of synthetic antimalarials (PSA) in the long term on the risk of occurrence of hospitalization, intubation or Covid-19 deaths ”, conclude its authors.

"Even if the observational nature of the study does not allow to formally conclude that there is no benefit from synthetic antimalarials for the prevention of a severe form of Covid-19, these results do not argue in favor of using preventive of hydroxychloroquine in the population, including the population most at risk, and this outside of dedicated therapeutic trials ”, insist the researchers.

They studied "all of the people who received at least six reimbursed deliveries of synthetic antimalarials (hydroxychloroquine or chloroquine) between January 1, 2019 and February 15, 2020, the last of which during the last quarter of 2019 or early 2020" .

Hydroxychloroquine prescribed for autoimmune diseases

Hydroxychloroquine, derived from the antimalarial chloroquine, is particularly prescribed in the treatment of autoimmune diseases such as lupus and or rheumatoid arthritis.

The results even highlight "a risk of hospitalization, intubation and death linked to Covid-19 among patients on long-term PSA compared to the general French population".

But "the analyzes carried out suggest that this extra risk is explained by the characteristics linked to the underlying chronic pathology" of these patients, "in particular the co-medication with oral corticosteroids, rather than by the exposure to PSA itself".

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Most clinical trials testing hydroxychloroquine were stopped at the end of May, after the publication of a negative study in the medical journal The Lancet (later withdrawn after suspicion of fraud), then after the results in early June of a a large British trial, Recovery, that hydroxychloroquine shows "no beneficial effect" for patients with Covid-19.

In France, the derogatory authorization to prescribe hydroxychloroquine in hospitals for the treatment of Covid-19, outside of clinical trials, was withdrawn on May 4.

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