Thalidomide: Proteolysis required for growth is phytotoxicity October 30th 4:27
Research groups such as Tokyo Medical University show that thalidomide, which was used globally by pregnant women and caused phytotoxicity, is likely to cause disabilities by degrading proteins essential for early development, such as limbs. Revealed in research using animals.
“Thalidomide” was prescribed by the 1960s to relieve the “morning” of pregnant women, and the phytotoxicity that causes serious damage to the limbs and ears of born babies has become a global problem. Is not exactly known and is now used again to treat some cancers and leprosy.
A group such as specially appointed professor Hiroshi Handa of Tokyo Medical University administered thalidomide to a fish egg called zebrafish and analyzed it. The protein that is indispensable for the growth of the fin called "decomposes" and it has been found that the growth does not progress sufficiently.
“P63” is known to be a protein necessary for the development of limbs and ears in humans, and it is highly possible that the group has decomposed this protein to cause phytotoxicity.
Prof. Handa says, “It is now being administered to some cancers, and by understanding the mechanism, it will be safer to use.”